New investigator Morgridge explores the role of diet and metabolism in stem cell function

Daniela Drummond-Barbosa has been fascinated with genetics her complete life, however her greatest turning level in science got here due to the common-or-garden fruit fly, Drosophila melanogaster.

Drummond Barbosa will be part of the Moorridge Analysis Institute and Division of Genetics on the College of Wisconsin-Madison On July 1, 2022. She got here to Wisconsin from Johns Hopkins College, the place she has been a professor of biochemistry and molecular biology since 2009.

Daniela Drummond Barbosa

Drummond Barbosa is a acknowledged chief in her area working to know the metabolic and physiological components that hyperlink the conduct of stem cell lineages to weight loss program, stress, and different systemic inputs. The work has main implications for understanding the genetic drivers of stem cell problems, weight problems, infertility, and a wide range of metabolic-related illnesses.

The spine of Drummond Barbosa’s analysis is the archetypal fruit fly organism, however this was not the case early in her educational profession. She acquired her Ph.D. from Yale College in 1995 underneath famend genetics professor Daniel DiMaio, who research the hyperlinks between HPV and most cancers. Whereas most of her work was utilizing tissue tradition to review bovine papillomavirus, she could not assist however captivate fellow graduate college students utilizing flies.

“In my lab, I used to be annoyed by doing analysis on cultured cells, as a result of our outcomes can range tremendously relying on the kind of cell tradition we had been utilizing,” she says. “On the similar time, I used to be watching graduate college students engaged on fruit flies who may make a mutation in a single gene, and immediately one thing would change utterly with respect to the fly. So there was little question that what they had been learning was essential.”

“That’s once I completely fell in love with flies. I used to be in awe of how they had been ready to determine such a fancy hierarchy of genes simply by mutant fly embryos! This planted the seed that these flies are actually cool and extremely highly effective.”

Daniela Drummond Barbosa

Her curiosity solidified when taking the “Cells in Growth” course, the place she was launched to the Nobel Prize-winning work of scientists who’ve used Drosophila and the facility of genetics to find out how an embryo develops – primarily by following the hierarchy of genes that decide the complete sample of division, together with the place and the way it develops Head, chest and stomach.

“That is once I completely fell in love with flies,” says Drummond Barbosa. “I used to be in awe of the way in which they had been ready to determine such a fancy hierarchy of genes simply by mutant fly embryos! This planted the seed that these flies are actually cool and extremely highly effective.”

Drummond Barbosa says her lab is involved in elementary questions on how tissues develop from stem cells, how fertility is managed, and the way an organism’s physiology pertains to replica. The crew can be how the exterior surroundings, physiology and replica are associated. Particularly, they examine the robust relationship between diets, weight problems and infertility.

“Scientists within the area of stem cells are starting to appreciate that the problem of weight loss program and physiology is basically essential,” she says. “Previously, metabolism was thought to have solely a housekeeping operate, one thing your physique must do to provide vitality and the molecular constructing blocks. And so they considered adipose tissue as only a place to retailer further vitality, then mobilize it later. However on the time These days, there’s a rising realization of how metabolism performs extra complicated roles and might truly drive cell destiny choices.”

Drummond Barbosa says she “could not dream of a greater place” to proceed her curiosity-driven work than Morgridge and UW-Madison. She says the metabolism analysis neighborhood is among the largest and most achieved she’s encountered, and it’ll enable her to ask new questions in her analysis.

“I used to be in search of a spot the place individuals can be captivated with science for the sake of science,” she says. “I positively belong to the ‘discovering it from scratch’ science wing.”

Drummond Barbosa is strongly dedicated to coaching the following era of scientists from all backgrounds, together with ladies and teams traditionally excluded from science. She says her standing as a Latina girl in science might assist her seem extra carefully to a various group of scholars.

“I am very carefully concerned with all of my interns,” she says. “Over time, you get to know their strengths and what areas would possibly want some further assist. Is that this somebody who must assume extra deeply? Or is that this somebody who’s so misplaced within the particulars that they can not see the forest for the timber? Or is it that This individual is somebody who works actually arduous, however in some way is not alert? Or somebody who may need misplaced his motivation? You possibly can’t delegate these questions and find out how to resolve them to another person in your lab.”

Drummond Barbosa was born in Los Angeles and raised in Belo Horizonte, Brazil, the place she lived till she acquired her Bachelor’s diploma. After receiving her Ph.D. from Yale College in 1995, she did postdoctoral coaching on the Carnegie Establishment for Science, and in 2002 grew to become an Assistant Professor of Mobile Biology and Progress at Vanderbilt College Medical Middle.

“Daniela’s analysis hyperlinks stem cell biology with metabolism, and is subsequently a terrific match for the Morgridge Institute,” mentioned Morgridge CEO. Brad Schwartz. “Even earlier than Daniela acquired right here, she sparked many conversations along with her colleagues at Morgridge about potential analysis collaborations, which is precisely the type of scientist we’re striving for. We’re thrilled to have her on our crew.”